Angiomatoid Fibrous Histiocytoma, A Great Mimicker – A Short Series of ۳ Cases with EWSR۱ Fusion
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 18، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-18-1_013
تاریخ نمایه سازی: 26 اردیبهشت 1402
Abstract:
Angiomatoid Fibrous histiocytoma (AFH) is a rare soft tissue neoplasm that is often misdiagnosed initially. It is commonly encountered in the superficial extremities of children and young adults. It is composed of a nodular proliferation of bland looking spindled to ovoid cells, some with variant histology and characterized by EWSR۱ fusion. We, herein, present three such cases, who presented with swelling in the right leg (case ۱), right forearm (case ۲), and right thigh (case ۳). Case ۲ presented in the fourth decade with a large swelling compared to the other two cases that presented in ۳rd decade with a small swelling. Histologic examination of case ۲ showed extensive myxoid changes making it diagnostically challenging. All three cases showed EWSR۱ fusion with a break-apart probe. Follow-up was uneventful in all three cases. AFH, although it is a benign neoplasm, is a great mimicker of various low-grade spindle cell sarcomas. Awareness of this entity with its various histomorphological variants is necessary to accurately diagnose this lesion.
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Authors
Aparna C
Department of Pathology, Kidwai Memorial Institute of Oncology, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India
Ashwini Nargund
Department of Pathology, Kidwai Memorial Institute of Oncology, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India
Geeta Patil Okaly
Department of Pathology, Kidwai Memorial Institute of Oncology, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India
Usha Amirtham
Department of Pathology, Kidwai Memorial Institute of Oncology, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India
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