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Investigating the effect of silymarin and propofol on liver and lipid factors in male Wistar rats

Publish Year: 1401
Type: Conference paper
Language: English
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CONFITC07_054

Index date: 24 May 2023

Investigating the effect of silymarin and propofol on liver and lipid factors in male Wistar rats abstract

Background: Silymarin, a flavonolignan from silybum marianum, consumed because of its wonderful hepatoprotective feature. Silymarin in a suitable bioavailability has been used to treat some of liver disorders that the most important of its effectiveness mechanism include antioxidant activity. The purpose of this study is to investigate the effect of silymarin on propofol-induced increase in lipid factor levels in male Wistar rats.Method: Rats were divided into 4 groups: GpI: control group., received distilled water. GpII: propofol group., received propofol (4 mg/kg for 21 days., I.P.); GpIII: silymarin group., received silymarin (100 mg/kg, gavage for 21 days); GpIV: Pro-silym-group (4 mg/kg propofol., I.P. and silymarin 100 mg/kg., gavage, for 21 days). On the 22nd day, all rats were anaesthetized and plasma collected to estimate AST, ALT, ALP, LDH, Bili-T, TG, Cho, HDL. The liver was removed for investigation of MDA, GPx, GSH, CAT and histopathology study. Results: Silymarin and propofol improved oxidative stress factors and hepatic enzymes. However, administration of propofol significantly increased triglycerides but did not increase cholesterol. Administering silymarin together with propofol had a modulating effect on propofol-induced increase in triglycerides.Conclusion: Propofol and silymarin improve the body's oxidative stress, but due to its lipid structure, propofol can increase triglycerides, which is a warning for patients with high triglycerides that silymarin can be considered as a protective option in this situation.

Investigating the effect of silymarin and propofol on liver and lipid factors in male Wistar rats Keywords:

Investigating the effect of silymarin and propofol on liver and lipid factors in male Wistar rats authors

Zahra Eslamifar

Department of Medical Laboratory Sciences, School of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran

Morteza Habibi Moghadam

School of Paramedical Sciences, Dezful University of Medical sciences, Dezful, Iran

Leila Jafaripour

Department of Anatomy, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran