Could Basal Uric Acid Levels Be an Important Biomarker for Prediction of Acute Renal Injury in Patients With Sepsis in the Intensive Care Unit?

Background: Sepsis is an important risk factor for the development of acute renal injury (ARI) among patients admitted to the intensive care unit (ICU). There are limited studies showing that increased uric acid level is an important risk factor for the development of ARI. The present study was carried out to find out whether increased basal uric acid levels play an important role in predicting the development of ARI and whether it could be used as a biomarker for this.Materials and Methods: This retrospective study included patients aged≥۱۸ years who were admitted to the ICU of Yüzüncü Yıl University Medical Faculty Hospital from September ۲۰۱۸ to December ۲۰۲۰. Group ۱ comprised ۱۰۰ patients developing ARI and group ۲ comprised ۱۱۰ patients who did not develop ARI. Laboratory test values and Simplified Acute Physiologic Score II (SAPS II) data on the first day of ICU admission were obtained from archive records.Results: During the ۱۰-day follow-up of patients included in the study, the ARI development rate was ۵۷.۳%. Basal serum uric acid levels were higher in group ۱ compared to group ۲ (P=۰.۰۰۱). Based on the results of the multivariate logistic regression analysis, basal serum uric acid values and albumin and SAPS II values had independent correlations with ARI (P<۰.۰۰۱).Conclusion: We believe that increased basal uric acid levels examined in patients admitted to the ICU with sepsis diagnosis may be an important biomarker for the prediction of ARI.

Keywords:

Uric acid , Acute renal injury , Sepsis , Intensive care unit