Assessment of Magnesium Sulfate Infusion in Combination with Ketorolac for the Pain Management in Intertrochanteric Fractures; A Randomized Clinical Trial
Publish place: The Archives of Bone and Joint Surgery، Vol: 11، Issue: 6
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_TABO-11-6_006
تاریخ نمایه سازی: 27 خرداد 1402
Abstract:
Objectives: Intertrochanteric fracture is a common fracture that mainly occurs in the elderly. Diverse pain management strategies have been applied; however, considering the age of the patients, analgesia-related complications should be concisely considered. The current study aims to evaluate the efficacy and adverse effects of Ketorolac plus placebo versus Ketorolac plus magnesium sulfate for pain management in intertrochanteric fractures. Methods: The current randomized clinical trial has been conducted on ۶۰ patients with intertrochanteric fractures assigned into two groups of treatment with Ketorolac (۳۰ mg) plus placebo (n=۳۰) versus Ketorolac (۳۰ mg) plus magnesium sulfate (۱۵ mg/kg) (n=۳۰). Pain scores using the visual analog scale (VAS), hemodynamic parameters, and complications (nausea and vomiting) were assessed at baseline and within ۲۰, ۴۰, and ۶۰ minutes after the interventions. Additional morphine sulfate requirements were compared between the groups. Results: Demographic characteristics in both groups were similar (P>۰.۰۵). All the assessments showed statistically significantly less pain severity in the magnesium sulfate/Ketorolac group (P<۰.۰۵), except for the baseline assessments (P=۰.۸۷۳). The two groups did not differ regarding hemodynamic parameters, nausea, and vomiting complaints (P>۰.۰۵). Although the frequency of additional morphine sulfate requirement was not different between the groups (P=۰.۰۶), the administered dose of morphine sulfate was significantly higher in those treated with ketorolac/placebo (P=۰.۰۰۲). Conclusion: Based on the findings of this study, Ketorolac alone or in combination with magnesium sulfate led to significant pain reduction in patients with intertrochanteric fractures admitted to the emergency ward; however, the combination therapy had superior outcomes. Further studies are strongly recommended. Level of evidence: II
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Authors
Bijan Heidari
Department of Orthopedics, School of Medicine, Besat Hospital, Hamadan, Iran
Rasoul Salimi
Department of Emergency Medicine, School of Medicine, Besat Hospital, Hamadan, Iran
Hossein Saremi
Department of Orthopedics, School of Medicine, Besat Hospital, Hamadan, Iran
Mostafa Arab Ghahestani
Department of Orthopedics, School of Medicine, Besat Hospital, Hamadan, Iran
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