Effects of radioiodine therapy on fertility indicators among men with differentiated thyroid cancer: A cohort study

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 122

This Paper With 8 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJRM-21-5_003

تاریخ نمایه سازی: 28 خرداد 1402

Abstract:

Background: Following thyroidectomy, radioiodine therapy is the standard management of differentiated thyroid cancer. The effects of such treatment on testicular function remained a concern for cases and clinicians. Objective: We aimed to observe changes in fertility indicators in men treated with ablation. Materials and Methods: In this prospective cohort study, ۱۸ men with differentiated thyroid cancer from June to December ۲۰۲۰ underwent thyroidectomy plus radioiodine therapy. Participants were grouped based on iodine dose (۸ men with ۳۰ mCi vs. ۱۰ men with ≥ ۱۵۰ mCi). Baseline values (VB) of the follicular stimulating hormone, luteinizing hormone, testosterone, and sperm analyses were measured ۳ wk before iodine ablation and repeated ۳ (V۳) and ۱۲ (V۱۲) months later. They were analyzed once as a whole and once based on their groups via ANOVA and Friedman's tests where appropriate. Results: The mean age of participants was ۳۵.۶۱ ± ۹.۷۴ yr. Follicular stimulating hormone levels showed a significant trend among all participants (VB: ۱۲.۵۱ ± ۱.۷۲, V۳: ۱۳.۵۴ ± ۱.۴۱, and V۱۲: ۱۳.۱۰ ± ۱.۶۷ IU/mL; p < ۰.۰۰۱). Luteinizing hormone showed a similar pattern (VB: ۴.۹۸ ± ۱.۲۷, V۳: ۵.۶۵ ± ۱.۲۹, and V۱۲: ۵.۲۱ ± ۰.۹۵ IU/mL; p < ۰.۰۰۱). Testosterone levels did not differ significantly from baseline. Sperm count decreased at the first checkpoint and returned to normal after ۱۲ months (VB: ۳۸.۲۲ ± ۱۹.۴۰, V۳: ۳۲.۰۵ ± ۱۷.۹۶, and V۱۲: ۳۶.۶۶ ± ۱۸.۸۱ million/mL; p < ۰.۰۰۱). Sperm motility and morphology did not change significantly. Conclusion: Our research showed that even less than ۵ GBq irradiation could induce a transient testicular dysfunction in the first ۳ months of therapy, but it was mostly reversible after ۱۲ months.

Authors

Salman Soltani

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Atena Aghaee

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Seyed Rasoul Zakavi

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Mahdi Mottaghi

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Maryam Emadzadeh

Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Sahar Rahmani

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Soheil Kasaeian Naeini

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • National Cancer Institute. New research into thyroid cancer. ۲۰۲۱. Available ...
  • National Cancer Institute. SEER stat fact sheets: Thyroid cancer. SEER ...
  • Esquerré-Lamare C, Isus F, Moinard N, Bujan L. Sperm DNA ...
  • Nies M, Arts EGJM, van Velsen EF, Burgerhof JGM, Kobold ...
  • van Velsen EFS, Visser WE, van den Berg SA, Kam ...
  • Yaish I, Azem F, Gutfeld O, Silman Z, Serebro M, ...
  • Wichers M, Benz E, Palmedo H, Biersack HJ, Grünwald F, ...
  • Fard-Esfahani A, Emami-Ardekani A, Fallahi B, Fard-Esfahani P, Beiki D, ...
  • Canale D, Ceccarelli C, Caglieresi C, Moscatelli A, Gavioli S, ...
  • Bourcigaux N, Rubino C, Berthaud I, Toubert ME, Donadille B, ...
  • Sayan M, Cassidy R, Butker EE, Nanda RH, Krishnamurti L, ...
  • Rosario PW, Xavier ACM. Recombinant human thyroid stimulating hormone in ...
  • Ambigapathy JS, Kamalanathan S, Sahoo J, Kumar R, Perumal NL. ...
  • Alahmar A, Dutta S, Sengupta P. Thyroid hormones in male ...
  • Zhang L, Huang Y, Zheng Y, Cai L, Wen J, ...
  • نمایش کامل مراجع