Metabolic flare phenomenon mimicking disease progression on ۱۸Flouride– Fluorodeoxyglucose PET/CT scan in breast cancer treated with paclitaxel-based chemotherapy
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNMB-11-2_010
تاریخ نمایه سازی: 28 خرداد 1402
Abstract:
۱۸F-fluorodeoxyglucose Positron emission tomography (۱۸F-FDG PET/CT ) is now being used as a single modality for metastatic workup and response evaluation in breast cancer. An increase in metabolic activity indicates disease progression; however, metabolic flare should be kept in mind. Metabolic flare is a well-documented phenomenon reported in metastatic breast and prostate cancer. Despite a favorable response to therapy, there is a paradoxical increase in radiopharmaceutical uptake. The flare phenomenon with various chemotherapeutic and hormonal agents is well acknowledged in bone scintigraphy. However, very few cases have been documented on PET/CT. Increased uptake may be noted after treatment is instituted. The increased osteoblastic activity is associated with the healing response of bone tumors. We report a case of treated breast cancer. She presented with metastatic recurrence after four years of initial management. The patient was started on paclitaxel chemotherapy. Serial ۱۸F- FDG PET/CT demonstrated metabolic flare and complete metabolic response.
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Authors
Vijay Singh
Department of nuclear medicine SGPGIMS, India
Shivangi Dixit
Department of nuclear medicine SGPGIMS, India
Manish Ora
Department of nuclear medicine SGPGIMS, India
Aftab Nazar
Department of nuclear medicine SGPGIMS, India
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