[۶۸Ga] Ga-Pentixafor diffuse bilateral Adrenal & Breast uptake in a patient with High-grade Glioma: A note of caution on normal variants

[۶۸Ga] Ga-labeled C-X-C motif receptor۴ as a novel radio-ligand using PET/CT has been investigated for tracing various kinds of solid and hematopoietic malignancies in recent years. High-grade Glioma (WHO classification ۲۰۱۶ grade III and IV) shows elevated levels of CXCR۴ ligand expression in the affected tumoral cells. Healthy and non-affected organ cells express low-level CXCR۴ ligands density. We performed [۶۸Ga] Ga-Pentixafor (Pars-Cixafor™) PET/CT in a patient with high-grade Glioma (anaplastic oligodendroglioma WHO grade III) with no other documented medical condition and history. In addition to the Pentixafor-avid tumor remnant in the PET/CT images, we observed mild symmetrical bilateral uptake in the fibro glandular tissue of the breasts and moderate CXCR۴(Pentixafor) avidity in both adrenal glands without any discernable pathology and abnormal density changes in the CT component of the study. Attention should be paid to the interpreting [۶۸Ga] Ga-Pentixafor PET/CT examination and its normal uptakes and variants.

Keywords:

CXCR۴ , High-grade Glioma , Adrenal , Breast , PET/CT