Prevalence of Antibiotic Resistance to Isonicotinylhydrazide and Rifampicin in Culture Positive Pulmonary Tuberculosis Patients from ۲۰۱۴ to ۲۰۱۶ in Zahedan City, Iran

Background: One third of the world’s population is infected with TB, and the disease is known as the second deadly global infection, even more severe than measles. The disease kills about ۲ million people a year. Approximately ۸ million people in the world are affected by advanced tuberculosis (TB). Objective: The current study aimed to determine the frequency of resistance to the antibiotics isoniazid and rifampin in positive culture pulmonary TB patients in Zahedan city during ۲۰۱۳-۲۰۱۶. Methods: This descriptive cross-sectional study studied ۱۰۰ samples from patients who referred to Boo-Ali hospital of Zahedan city from ۲۰۱۴ to ۲۰۱۶. First, the isoniazid solution was prepared, and then the rifampin solution was prepared. After that, ۲۰۰ μL of mycobacterium suspension was added to the antibiotic and antibiotic-free control. Results: Of ۱۰۰ patients participating in the study, ۵۰ (۵۰%) were male and ۵۰ (۵۰%) were female. Participants had an average age of ۵۱.۶۹ ± ۲۰.۴۱ years (۹۵-۱۲ years), ۷۹ (۷۹%) were Iranians and ۲۱ (۲۱%) were Afghans. Of the ۱۰۰ samples, ۵۵ (۵۵%) were from the year ۲۰۱۳, ۲۱ (۲۱%) were from ۲۰۱۴, ۱۰ (۱۰%) were from ۲۰۱۵, and ۱۴ (۱۴%) were from year ۲۰۱۶. The samples examined showed that ۴ (۴%) were resistant and ۹۶% were sensitive. Conclusion: The results of the current study showed that out of ۱۰۰ samples, ۴ cases (۴%) had resistance and ۹۶% were sensitive; ۲% were resistant to isoniazid, and ۲% were resistant to isoniazid and rifampin.

Keywords:

Pulmonary tuberculosis , Drug resistance , Tuberculosis (TB)