Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, ۲۰۱۸–۲۰۱۹

Andi Yasmon; Paulina Rosa Evriarti; Yeva Rosanna

Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, 2018–2019

Publish place: Iranian Journal of Medical Microbiology، Vol: 17، Issue: 2

Publish Year: 1401

Type: Journal paper

Language: English

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https://civilica.com/doc/1690517

Document National Code:

JR_IJMM-17-2_016

Index date: 9 July 2023

Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, 2018–2019 abstract

Background and Aim: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring. One of the causes is probably the diphtheria toxin repressor (dtxR) gene, which influences toxin expression. In this study, the gene was characterized to determine the mutations that affect the DtxR protein. Materials and Methods: The dtxR genes of 10 C. diphtheria strains isolated in Jakarta were amplified by conventional PCR. The PCR products were directed to DNA sequencing by using overlapping primers. Results and Conclusion: No mutations showed amino acid changes. We propose that the DtxR protein is conserved among bacterial strains isolated from Jakarta.

Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, 2018–2019 Keywords:

Corynebacterium diphtheriae , dtxR , Mutation , Phylogeny tree , Corynebacterium diphtheriae , dtxR , جهش , درخت فیلوژنی

Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, 2018–2019 authors

Andi Yasmon

Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital. Jl.Pegangsaan Timur ۱۶, Cikini, Jakarta Pusat ۱۰۳۲۰, Jakarta,Indonesia

Paulina Rosa Evriarti

Biomedical Science Graduate Program, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.۵, Jakarta Pusat ۱۰۳۲۰, Jakarta, Indonesia

Yeva Rosanna

Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital. Jl.Pegangsaan Timur ۱۶, Cikini, Jakarta Pusat ۱۰۳۲۰, Jakarta, Indonesia

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