Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Arterial Stiffness in Persian Cohort Study

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_PSQ-11-2_005

تاریخ نمایه سازی: 19 تیر 1402

Abstract:

Introduction Liver function tests such as AST/ALT ratio may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether AST/ALT was associated with arterial stiffness in a large population-based cohort of apparently healthy Persian women and men.Material and Methods: To evaluate arterial stiffness non-invasively, Pulse Wave Velocity (PWV) and Augmentation Index (AI) were measured in ۵۰۳۱ healthy adults. Laboratory parameters, including AST and ALT, were measured after all subject's blood samples were collected. The one-way-ANOVA, the Kruskal-Wallis, and chi-square tests were used to compare the AST/ALT ratio among groups with baseline characteristics of participants following the calculation of AST: ALT through the division of AST levels by ALT levels. The univariate linear regression model was used to assess the association between mean pulse wave velocity (PWV) and AST/ALT ratio quartiles. Results: The results showed no statically significant difference in Age, HR, and MET among the different AST/ALT groups. Univariate analysis displayed that age, SBP, DBP, FBS, TG, MET, Fatty liver status, and hypertension status were positively correlated with Mean PWV. Evaluation of univariate linear regression models presented that AST/ALT has a significant correlation with Mean PWV (β = -۰.۱۳۹, ۹۵% confidence interval (CI): -۰.۰۳۲ to -۰.۰۲۱, P-value < ۰.۰۰۱). We found that there was no linear relationship.Conclusions: According to the present study results, there was a significant negative correlation between AST/ALT with PWV. Moreover, a non-linear relationship between AST/ALT and PWV was observed as well.

Authors

Sahar Sobhani

Persian Cohort Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Sara Raji

Persian Cohort Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Fatemeh Roudi

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohamad Amin Bakhshali

Postdoc Researcher, Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Dina Javidjam

Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Effat Saghi

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Ataee

School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Saeed Eslami Hasan Abadi

Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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