Synthesis of biological metal-organic framework by biomineralization method for the delivery of ۵-FU

In the current research, inspired by the biomineralization process, a biological metal-organic framework (BioMOF) was created for the protection, encapsulation and controlled release of ۵-FU drug. For this purpose, biocompatible nanoporous metal-organic framework based on sulfonamide was synthesized as a carrier for the delivery of ۵-FU drug in the presence of protein in aqueous medium at room temperature. Some characterization techniques such as scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR) were used. In the end, the MTT method was used to investigate the toxicity of the synthesized composite. The obtained results showed that the protein/۵-Fu@BioMOF can be effective for the cancer therapy.

Keywords:

Biological metal organic framework (BioMOF) , Fluorouracil(۵-Fu) , Biomineralization and cancer therapy.