The Effect of Nucleus Size on the Cell Dose in Targeted Radionuclide Therapy – A Monte Carlo Study
Publish place: Journal of medical signals and sensors، Vol: 10، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMSI-10-2_006
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Background: Nowadays, the use of radiopharmaceuticals in medicine is unavoidable. Depending
on the distribution of the radiopharmaceutical in the cells, the nucleus absorbed dose changes
by the variations in their geometry size. Therefore, this study aims to investigate the S‑value by
the variation of nucleus size using Geant۴ toolkit. Methods: Two spherical cells with a variety
of nucleus size have been considered as the cancerous cell. Monoenergetic electrons ranging
from ۵ to ۳۰۰ keV are distributed uniformly. The S‑value for four target‑source components
(including Nucleus←Cytoplasm, Nucleus←Cell surface, Nucleus←Nucleus, and Nucleus←Nucleus
surface) is computed and plotted. Then, the obtained data are compared with analytical Medical
Internal Radiation Dose (MIRD) data. Results: In Nucleus←Cytoplasm compartment for electrons
below ۱۰ keV, obtained S‑values show a slight decrease for the nucleus in the radii of around half
of the cell radius and then S‑values increase with the increase in the nucleus radii. In the S‑value of
Nucleus←Cell surface, for all electron energy levels, a slight decrease observed with the increase
of nucleus radii. For Nucleus←Nucleus and Nucleus←Nucleus surface cases, with an increase in
the size of the cell nucleus, a sharp reduction in the S‑values is detected. Conclusion: It can be
concluded that for the beta emitters with low‑energy radiation (<۴۰ keV), the S‑value is heavily
dependent on the nucleus size which may affect the treatment of small tumors. While for the beta
emitters with higher‑energy radiation (>۱۰۰ keV), the size of the nucleus is not very noticeable in
the induced S‑value.
Keywords:
Authors
Ebrahim Kouhkan
Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nahid Chegeni
Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Amjad Hussain
Department of Medical Physics, Cancer Care Manitoba, Winnipeg, MB, Canada