Investigating the Dosimetric Characteristics of Microbeam Radiation Treatment
Publish place: Journal of medical signals and sensors، Vol: 11، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMSI-11-1_006
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Background: High‑radiation therapeutic gain could be achieved by the modern technique of
microbeam radiation treatment (MRT). The aim of this study was to investigate the dosimetric
properties of MRT. Methods: The EGSnrc Monte Carlo (MC) code system was used to transport
photons and electrons in MRT. The mono‑energetic beams (۱ cm × ۱ cm array) of ۵۰, ۱۰۰, and
۱۵۰ keV and the spectrum photon beam (European Synchrotron Radiation Facility [ESRF]) were
modeled to transport through multislit collimators with the aperture’s widths of ۲۵ and ۵۰ μm
and the center‑to‑center (c‑t‑c) distance between two adjacent microbeams (MBs) of ۲۰۰ μm. The
calculated phase spaces at the upper surface of water phantom (۱ cm × ۱ cm) were implemented in
DOSXYZnrc code to calculate the percentage depth dose (PDD), the dose profile curves (in depths
of ۰–۱, ۱–۲, and ۳–۴ cm), and the peak‑to‑valley dose ratios (PVDRs). Results: The PDD, dose
profile curves, and PVDRs were calculated for different effective parameters. The more flatness
of lateral dose profile was obtained for the ESRF spectrum MB. With constant c‑t‑c distance, an
increase in the MB size increased the peak and valley dose; simultaneously, the PVDR was larger for
the ۲۵ μm MB (۳۳.۵) compared to ۵۰ μm MB (۲۱.۹) beam, due to the decreased scattering photons
followed to the lower overlapping of the adjacent MBs. An increase in the depth decreased the
PVDRs (i.e., ۵۴.۹ in depth of ۰–۱ cm). Conclusion: Our MC model of MRT successfully calculated
the effect of dosimetric parameters including photon’s energy, beam width, and depth to estimate the
dose distribution.
Keywords:
Authors
Mansour Zabihzadeh
Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences- Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences- Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University
Atefeh Rabiei
Department of Medical Physics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences
Hojattollah Shahbazian
Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Sasan Razmjoo
Department of Clinical Oncology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran