Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form
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زبان: English
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تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Diabetes is one of the major medical problems in the world. The discovery of insulin was a milestone in
the history of medical science. This legendary invention has completed ۱۰۰ years of its journey. Through
this ۱۰۰-year journey, many important events have taken place, and many modifications have been made
to make it convenient for commercialization and patient compliance. After the antidiabetic activity of
the pancreatic extract was discovered, the bovine and pork insulin came into use. Then, recombinant
human insulin was discovered. Now long-acting to rapid-acting insulin forms are available (e.g., insulin
pens, insulin pumps, and the like), and different systems are in use to deliver them to the body, but all
these insulins are in invasive dosage forms and have some disadvantages, too. As we are using the oral
form of most medicines, we prefer the oral form of insulin. Therefore, the concern is now to develop the
oral dosage form of insulin. Some proposed oral dosage forms are at different stages of the clinical trial
such as classical dosage forms, enzyme inhibitors, unnatural amino acids, nanoparticles, cell-penetrating
peptides, and so on. Since the oral forms of insulin create some limitations and confusion, further research
is required to solve these problems. Accordingly, the aim of the review was to predict the possibility of
developing marketable oral insulin.
Keywords:
Oral insulin , ۱۰۰ years of insulin , Diabetes , Current forms of insulin , Pancreas , Recombinant
technology
Authors
Ananya Saha
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Arifa Sultana
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Fahmida Yesmin
Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-۱۰۰۰, Bangladesh
Tahmina Akter
Department of Physiology, Dhaka Medical College, Dhaka ۱۰۰۰, Bangladesh