Prospects of BNAbs in Management of HIV/AIDS
Publish place: Journal of Health Reports and Technology، Vol: 7، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJHLS-7-2_001
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
HIV remains a global problem due to the lack of a therapy
that can completely wipe out the virus from the body
system of infected individuals (۱). Antiretroviral regimens
(ARVs) have helped greatly in the fight against HIV as a lot
of deaths have been prevented (۱). Antiretroviral regimens
have helped in reducing viral replication of HIV and also
to increase the life expectancy of individuals infected with
HIV (۱). Although antiretroviral regimens have been highly
effective, the viral reservoir cannot be cleared by antiretroviral
regimens, and therefore, lifelong use of antiretroviral
regimens is the only option for people living with HIV (۲).
Meanwhile, broadly neutralizing antibodies (BNAbs)
are being evaluated for their potential as long-acting alternatives
to the use of antiretroviral regimens in HIV prevention
and therapy (۳). BNAbs may be able to protect against
HIV-infection and this may help to prevent people who are
not living with HIV from being infected with the virus in
the future (۱). Also, the use of BNAbs as a treatment has
shown potential in clinical studies (۲) and it has also been
reported that BNAbs may have prospects in the clearance
of viral reservoir by interacting with the surface receptors
of infected cells using the FC Domain of the antibody (۱).
Furthermore, it has been reported that the main target for
neutralizing antibodiesmaybe the BNAbsCD۴receptor on
the T-cells (۴).
Keywords:
Authors
Gabreiel Ilerioluwa Oke
Department of Medical Laboratory Science, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Precious Fadele
Department of Medicine, University of Nigeria, Nsukka, Nigeria
Yusuff Adebayo Adebisi
Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
Melody Okereke
Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria