Elevated Levels of Anti-SARS-Cov۲ IgG Antibody in Health Care Workers in Hospitals From Hamadan Province, Iran: A Prospective Study
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شناسه ملی سند علمی:
JR_JCMI-9-2_007
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Aim: Seroprevalence among health care workers (HCWs) has been estimated in different studies in various
regions and countries. This study aimed to screen the immunoglobulin M (IgM) and IgG seroprevalences
and to assess the durability of IgG seropositivity, as well as the incidence of subsequent severe acute
respiratory syndrome coronavirus ۲ (SARS-CoV-۲) infection in a group of Iranian HCWs.
Methods: This voluntary serological screening was prospectively performed on ۸۰۰ HCWs (۴۹۲ females
and ۳۰۸ males) in Hamadan between November ۲۰۲۰ and February ۲۰۲۱. Anti-SARS-CoV-۲ IgG and IgM
antibodies were assessed by the enzyme-linked immunosorbent assay method at two-time intervals.
Results: Overall, ۲۴۳ out of ۸۰۰ (۳۰.۳۸%) and ۶۶ (۸.۲۵%) cases were IgG and IgM seropositive at their first
antibody assessment, respectively. The male staff had a higher seroprevalence than females (۳۱.۴۹% vs.
۲۹.۶۷% for IgG, P = ۰.۵۹ and ۱۰.۳۹% vs. ۶.۹۱% for IgM, P = ۰.۰۸). Higher prevalences for both antibodies
were found in the age group of ۳۰-۳۹.۹ years (P = ۰.۱۲ and P = ۰.۰۵, respectively). In the second antibody
screening, ۸۱ (۵۶.۶%) cases were IgG seropositive. The mean titer of the first IgG antibody assessment in
seropositive cases was lower than that of the second titer (۲.۹۵ ± ۲.۰۷ vs. ۵.۰۸ ± ۴.۰۱ cut-off index (COI)
, P = ۱.۴×۱۰-۵). Moreover, the comparison of the first and second IgG titers among ۸۱ seropositive cases
demonstrated a significantly increased level of anti-SARS-CoV-۲ antibody (۵.۰۸ ± ۴.۰۱ vs. ۳.۴۹ ± ۲.۴۱ COI,
P = ۰.۰۰۲).
Conclusions: Our findings revealed that the mean level of the anti-SARS-CoV-۲ IgG antibody was
significantly increased in the seropositive individuals after ۲ months of follow-up.
Keywords:
Authors
Ebrahim Jalili
Department of Emergency Medicine, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Saeid Bashirian
Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Reza Faryabi
Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mina Noroozbeygi
Department of Immunology, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran