A Comparative Study of Effect of Oral Melatonin Versus Oral Midazolam as Premedicant in Children Undergoing Surgery Under General Anesthesia

Background: Preoperative anxiety in children is associated with multiple post-operative outcomes like post-operative regressive behavioral disturbances, prolonged distress in the recovery phase, eating disorders, and bedwetting. The present study was designed to use low-dose oral melatonin versus oral midazolam in relieving pre-operative anxiety in children in the Indian population. Materials and Methods: A prospective randomized comparative study was conducted on children aged between ۲ to ۱۰ years of age scheduled for elective surgeries under general anesthesia are included in the study. This study was conducted with a sample size of ۷۰. Patients were randomly distributed into two groups of ۳۵ content. Group A (received ۰.۲mg/kg melatonin as premedical) and group B (received ۰.۵mg/kg midazolam as premedical). Results: Mean induction dose of propofol in the melatonin group was ۵۲.۱۴۳+ ۱۸.۳۶ mg and in the midazolam, the group was ۴۸.۷۱۴ + ۱۶.۶ mg. In our study, ۹۰ minutes after premedication, the anxiety score was less in the midazolam group. There was no statistically significant difference between the sedation scores in melatonin and midazolam. Conclusion: Low-dose melatonin (۰.۲mg/kg) is not an effective alternative premedicant in children to alleviate preoperative anxiety compared to midazolam.

Keywords:

Melatonin , Midazolam , Pre-operative anxiety , Anesthesia , Propofol