Effect of PTX drug on F۱۲۷ oil-in-water microemulsions: turbidity/transparency studies

Microemulsions are composed of nanometer-sized droplets of an immiscible liquid dispersed in another liquid. The components of a microemulsion are water, oil, a surfactant, and a cosurfactant, which is usually a short-chain alcohol. Surfactant-stabilized microemulsions are perfect nanocarrier systems to deliver therapeutic agents such as drugs within living systems by encapsulation into their nanocores to get protection against degradation, and the controlled release of the drug at a therapeutically optimal rate with an good bioavailability. drug-loaded microemulsions are composed of oil, a surfactant, a co-surfactant, a drug and water. In the current effort, solubilization capacity of the Paclitaxel (PTX), oil , and oil+PTX into Pluronic (F۱۲۷) pluronic microemulsions was studied as a function of F۱۲۷ concentration through simple turbidity or transparency experiments. This specific concentration of F۱۲۷ was different for three systems mentioned. We also observed that by increasing sodium caprylate fatty acid in the system , solutions became transparent. By the simple logic, we were able to determine the optimal binding ratio of F۱۲۷ and/or SC to ethyl butyrate oil, Paclitaxel drug, and oil+ PTX in microemulsion.

Keywords:

PTX , F۱۲۷ , Turbidity , Pluronic , oil-in-water microemulsion.