سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs

Publish Year: 1401
Type: Journal paper
Language: English
View: 160

This Paper With 10 Page And PDF Format Ready To Download

Export:

Link to this Paper:

Document National Code:

JR_JABS-12-3_008

Index date: 22 July 2023

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs abstract

Background & Objective: Breast cancer is one of the most common cancers in the world. Treatment methods for this disease have been with poor results. In recent years, more attention has been paid to stem cells due to their cytotoxic properties. According to previous results, the effect of nanoquercetin on breast cancer cells in this study was used concomitantly with doxorubicin, which is a chemotherapy drug and in some patients has therapeutic resistance. Materials & Methods: The above study was performed on MCF7 and BT474 human breast cancer cells. Quercetin was synthesized, then different concentrations of 10, 20, 40, 80 and 160 of quercetin and 1, 2.5, 5 and 10 μg/ml of doxorubicin were prepared and two cell lines were treated for 24 h. MTT test was used to determine cell viability and flow cytometry test was used to determine the extent of apoptosis in both cell lines. Results: The results showed that MCF7 and BT474 cells that were affected by quercetin and doxorubicin, increasing the concentration of quercetin and doxorubicin decreased the survival of both cell lines within 24 h. The LC50 concentration was calculated for both cells treated with nanoquercetin 40 μg/ml and for doxorubicin doxorubicin (0.1 mg/ml). The results also showed that in both cell lines, an increase in cellular apoptosis occurred after incubation with quercetin and then incubation with doxorubicin. Conclusion: Comparison of doxorubicin (DOX), quercetin (QU) and quercetin and doxorubicin (QU-DOX) groups with controls shows that with the presence of quercetin-doxorubicin, it had a greater inhibitory effect on cancer cells.

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs Keywords:

Overcoming Drug Resistance in Breast Cancer Using Quercetin Nanodrugs authors

فاطمه ثریابین مبرهن

Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran

مریم تیموری

Department of Biology, Roudehen Branch, Islamic Azad University, Roudehen, Iran

مهدی پولادی

Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
Vineis P, Wild CP. Global cancer patterns: causes and prevention. ...
Pooladi M, Abad SK, Hashemi M. Proteomics analysis of human ...
Ebrahimi M, Teimouri M, Pooladi M. The synergistic anticancer traits ...
Teimouri M, Pooladi M. Anti-Angiogenic and Anti-Proliferative Effects of Physalis ...
Telli ML, Gradishar WJ, Ward JH. NCCN guidelines updates: breast ...
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. ...
Howell A, Cuzick J, Baum M, Buzdar A, Dowsett M, ...
Navya PN, Kaphle A, Srinivas SP, Bhargava SK, Rotello VM, ...
Ezzati M, Yousefi B, Velaei K, Safa A. A review ...
Lakshmi BA, Kim S. Quercetin mediated gold nanoclusters explored as ...
Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ. ...
Sarkar A, Ghosh S, Chowdhury S, Pandey B, Sil PC. ...
Deng XH, Song HY, Zhou YF, Yuan GY, Zheng FJ. ...
Klein S, Distel LV, Neuhuber W, Kryschi C. Caffeic Acid, ...
Lv L, Liu C, Chen C, Yu X, Chen G, ...
Liu S, Li R, Qian J, Sun J, Li G, ...
Murugan C, Rayappan K, Thangam R, Bhanumathi R, Shanthi K, ...
Niazvand F, Orazizadeh M, Khorsandi L, Abbaspour M, Mansouri E, ...
Baksi R, Singh DP, Borse SP, Rana R, Sharma V, ...
Zhou Y, Chen D, Xue G, Yu S, Yuan C, ...
Sun H, Jin H, Pang B, Zhao H, Yang R, ...
Lv L, Liu C, Chen C, Yu X, Chen G, ...
Liu K, Chen W, Yang T, Wen B, Ding D, ...
Fang J, Zhang S, Xue X, Zhu X, Song S, ...
نمایش کامل مراجع