The Effect of Simvastatin and Vitamin D Co-Administration on Rats Brain Function and Behavior: A Behavioral and Biochemical Study
Publish place: Journal of Advanced Biomedical Sciences، Vol: 12، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JABS-12-1_007
تاریخ نمایه سازی: 31 تیر 1402
Abstract:
Background & Objective: The simvastatin (Sim) is a lipophilic statin and can cross the blood-brain barrier. The role of vitamin D (Vit D) in brain development and function has been supported over the past decade. This study aimed to evaluate the effect of simvastatin on memory and anxiety levels in healthy male rats.
Materials & Methods: In this experimental study, ۳۶ male Wistar rats weighing ۲۵۰-۳۰۰ g were randomly divided into six groups (n=۶) including control, Vit D (۵ µg/kg/day; IP), Simvastatin (۱ mg/kg/day; orally) (SimL), Simvastatin (۱۰ mg/kg/day; orally) (SimH), SimL + Vit D and SimH + Vit D. After ۲۸ days, at the end of the treatment, the behavioral anxiety test and memory behavioral test were performed. Then, the rats were euthanized, and oxidative stress markers of the brain, serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and cholesterol levels were investigated. Data were analyzed by SPSS ۲۴ software and Tukey’s test.
Results: Co-administration of simvastatin and vitamin D significantly increased working memory, catalase activity, total antioxidant capacity, HDL-C, and decreased anxiety levels, malondialdehyde (MDA) concentration, cholesterol, and LDL-C compared to the control group (p<۰.۰۵). However, the administration of simvastatin and vitamin D alone did not significantly change the mentioned parameters compared to the control group (p>۰.۰۵).
Conclusion: Co-administration of simvastatin and vitamin D can improve brain function by reducing oxidative stress and cholesterol levels.
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Authors
محمد صالح رعنایی
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
فرح فرخی
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
فرین بابایی بالدرلو
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
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