Evaluation of Insulin and Estradiol in Women with Polycystic Ovary Syndrome and its Relationship With BMI

Background & Objective:  Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, which is characterized by ovulatory dysfunction and hyperandrogenism. This study was done to evaluate insulin and estradiol (E۲) in women with PCOS and its relationship with Body mass index (BMI). Materials & Methods: This case-control study included, ۱۰۴ women with polycystic ovary syndrome as a case group and ۱۰۰ women without polycystic ovary syndrome as a control group. Concentrations of insulin, glucose and E۲ were measured in fasting blood samples. Results: Insulin level was ۷.۰۲ ± ۳.۲۹ in control group, ۱۱.۴۱ ± ۳.۸۴ in the case group. FBS level was ۸۲.۷۵ ± ۷.۱۸ in control group versus ۸۴.۰۳ ± ۵.۸۲ in case group. E۲ level was ۷۰.۷۴ ± ۵۳.۰۳ in control group and ۶۰.۲۱ ± ۴۰.۵۸ in case group. The insulin resistance level was ۱.۴۵ ± ۰.۷۴ in the control group versus ۲.۳۷ ± ۰.۸۳ in case group. According to correlation analysis, the insulin variable had a significant positive association with BMI (p < ۰.۰۰۰۱, r=.۲۴۵), although no significant correlation was seen between E۲ and BMI (p-value = ۰.۲۴۵, r=.۰۹۲) Conclusion: Present data showed that E۲ levels were not different in PCOS and non-PCOS patients, but insulin levels in PCOS were significantly increased and PCOS women had significant insulin resistance which is dependent on BMI.

Keywords:

Polycystic ovary syndrome , Insulin , estradiol , BMI