Comparing The Effects of Selenium Nanoparticles and Selenium Nanocomposites on Food Intake and Anxiety-like Behaviors
Publish place: Journal of Advanced Biomedical Sciences، Vol: 11، Issue: 3
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 57
This Paper With 12 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JABS-11-3_006
تاریخ نمایه سازی: 31 تیر 1402
Abstract:
Background & Objective: Selenium nanoparticles (Se -NPs) and selenium nanocomposites (Se -NCs) have different biological effects. Therefore, the present study aimed to compare the effects of selenium nanoparticles and selenium nanocomposites (Se –NCs) on anxiety, food intake, and brain histology of rats.
Materials & Methods: Thirty-two male adult Wistar rats were randomly and equally divided into four groups. The control group received saline, the Selenium powder group received ۱ mg/kg /day selenium powder orally for ۲۱ days, and the selenium nanoparticle group received three weeks of oral gavage of Se –NPs. The selenium nanocomposites group received three weeks of oral gavage of nanocomposites. Finally, cumulative food consumption and anxiety-like behaviors were assessed, and, after that, rats were bled and sacrificed for further biochemical and histopathological investigations.
Results: Oral administration of Se powder at a dose of ۱ mg/kg /day for ۲۱ days had no significant effect on the brain superoxide dismutase (SOD), catalase (CAT) activities. There was also no significant change in the levels of brain glutathione concentration (GSH), brain MDA, and behavioral parameters. Selenium nanoparticles also showed no significant alterations in brain biochemical parameters, behavioral effects, and brain histology. The oral administration of Selenium nanocomposites significantly increased brain superoxide dismutase, catalase, and reduced glutathione content and had positive effects on behavioral parameters.
Conclusion: The present study showed that Se -NCs have behavioral effects and could induce significant biochemical changes in brain oxidative status.
Keywords:
Authors
محمد رضا حاجی نژاد
Department of Basic Sciences, Faculty of Veterinary , University of Zabol , Zabol, Iran
علیرضا سام زاده کرمانی
Department of Chemistry, Faculty of Basic Science, University of Zabol, Zabol, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :