Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial
Publish place: Trauma Monthly، Vol: 26، Issue: 6
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_TRAUM-26-6_002
تاریخ نمایه سازی: 13 مرداد 1402
Abstract:
Introduction: Use of tampons is one of the most common ways to treat epistaxis. This single Randomized clinical trial aimed to assess the efficiency of tranexamic acid (TA) in controlling different types of bleeding.Methods: From ۲۰۱۹ to ۲۰۲۰, ۱۲۰ patients with epistaxis, referred to the Imam Reza Hospital(Tabriz-Iran) emergency department, and were treated. The patients were randomly divided into control (tampon) and intervention (TA) groups. The control group received tetracycline-impregnated tampon, while TA-impregnated gauze was used for the intervention group.Results: The mean time needed to stop bleeding was significantly higher (p=۰.۰۱۱) in the control group (۱۸.۵۹±۲.۳۳ Min) than in the intervention group (۰۹.۳۳±۱.۴۷ Min). In most patients in the intervention group bleeding stopped in less than ۱۰ minutes; while in the control group. Bleeding in the majority of patients ceased within ۱۰ to ۲۰ minutes (p=۰.۰۱).Conclusion: The results indicate the beneficial effects of TA, as a drug with relatively low side effects in reducing bleeding time in patients with epistaxis. Thus, it can be used as a complementary drug, along with packing to stop bleeding.
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Authors
Nikzad Shahidi
Department of Otorhinolaryngology, Tuberculosis and Lung Disease Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mirmohammadtaghi Mortazavi
Department of Anesthesiology, Medicine Faculty, Tabriz University of Medical Sciences Tabriz, Iran.
Abbasali Dorosti
Department of Anesthesiology, Medicine Faculty, Tabriz University of Medical Sciences Tabriz, Iran.
Reza Movassaghi
Associated Professor of Anesthesia, Tuberculosis and Lung Disease Research Center, Medical Faculty, Tabriz University of Medical Sciences,Tabriz, Iran.