Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial

Nikzad Shahidi; Mirmohammadtaghi Mortazavi; Abbasali Dorosti; Reza Movassaghi

Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial

Publish place: Trauma Monthly، Vol: 26، Issue: 6

Publish Year: 1400

Type: Journal paper

Language: English

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https://civilica.com/doc/1711855

Document National Code:

JR_TRAUM-26-6_002

Index date: 4 August 2023

Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial abstract

Introduction: Use of tampons is one of the most common ways to treat epistaxis. This single Randomized clinical trial aimed to assess the efficiency of tranexamic acid (TA) in controlling different types of bleeding.Methods: From 2019 to 2020, 120 patients with epistaxis, referred to the Imam Reza Hospital(Tabriz-Iran) emergency department, and were treated. The patients were randomly divided into control (tampon) and intervention (TA) groups. The control group received tetracycline-impregnated tampon, while TA-impregnated gauze was used for the intervention group.Results: The mean time needed to stop bleeding was significantly higher (p=0.011) in the control group (18.59±2.33 Min) than in the intervention group (09.33±1.47 Min). In most patients in the intervention group bleeding stopped in less than 10 minutes; while in the control group. Bleeding in the majority of patients ceased within 10 to 20 minutes (p=0.01).Conclusion: The results indicate the beneficial effects of TA, as a drug with relatively low side effects in reducing bleeding time in patients with epistaxis. Thus, it can be used as a complementary drug, along with packing to stop bleeding.

Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial Keywords:

Bleeding , Tranexamic acid , Epistaxis , Emergency

Use of Tranexamic Acid for Controlling Epistaxis in the Patients Referring to the Emergency Department: Single-blind randomized clinical trial authors

Nikzad Shahidi

Department of Otorhinolaryngology, Tuberculosis and Lung Disease Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Mirmohammadtaghi Mortazavi

Department of Anesthesiology, Medicine Faculty, Tabriz University of Medical Sciences Tabriz, Iran.

Abbasali Dorosti

Department of Anesthesiology, Medicine Faculty, Tabriz University of Medical Sciences Tabriz, Iran.

Reza Movassaghi

Associated Professor of Anesthesia, Tuberculosis and Lung Disease Research Center, Medical Faculty, Tabriz University of Medical Sciences,Tabriz, Iran.