Effect of Lactobacillus delbrueckii on Blood Sugar in Diabetic Mice

Background and Aims: Probiotics are defined as live microorganisms that are beneficial to human health. Probiotics are commonly found in some foods such as dairy products or complementary tablets. A recent research shows that probiotics have a significant role in diabetes type ۱ and ۲ treatment. Among the variety of lactic acid bacteria, Lactobacillus strains are well known in probiotics for their different properties. The aim of this study is to investigate the effect of Lactobacillus delbrueckii PTCC۱۰۵۷ on diabetic mice blood sugar. Materials and Methods: sample mice were selected from the age range of ۶ to ۸ weeks. Then for converting the normal mouse to diabetic type, ۱۸۰ mg/kg streptozotocin was injected intraperitoneally. ۱۰ days later, the blood sugar of the mice was measured and the mice with higher than ۲۰۰ mg/dl of blood sugar were considered as diabetic mice. Finally, the diabetic mice were divided into two groups of experimental and control for next investigation. For a survey of probiotics effect on blood sugar, an amount of ۳×۱۰۶ CFU of L. delbrueckii was fed by gavage feeding approach daily during ۴ weeks and the blood sugar level was determined at the end of the week after streptozotocin injection. Results: the result showed that the diabetic mice blood sugar level significantly decreased conspicuously by feeding L. delbrueckii in comparison to diabetic control group. Conclusion: The result of this study suggests that L. delbrueckii can be impressive in diabetes treatment. However, another clinical study is needed for proving the exact effect of this probiotic on diabetes.

Keywords:

Diabetic mice , Lactobacillus delbrueckii , Probiotic