Medical Function of Bacterial Extracellular Vesicles
Publish place: Iranian Journal of Medical Microbiology، Vol: 12، Issue: 3
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJMM-12-3_001
تاریخ نمایه سازی: 16 مرداد 1402
Abstract:
Extracellular vesicles are nanoscale particles which were identified about fifty years ago. The studies have shown that all of the gram-negative bacteria secrete extracellular vesicles during their normal growth. Today, the production of membrane vesicles has been reported by gram-positive bacteria, parasites, fungi, and mycobacteria. Since these nanoscale particles carry many of the bacterial components such as DNA, RNA, protein, endotoxin, and virulence molecules, they play a very important role in interacting with the environment and other bacteria. For this reason, many of these vesicles are considered as the transmission of pathogens, antigenic protein compounds, and the development of non-cellular vaccines, as well as drug delivery agents. The studies, have been carried in this field so far, have been focused on the pathogenic and physiological roles of these nanostructures in cross-species relationships. The focus of this article is on the role of extracellular bacterial vesicles and pathological and physiological functions which contribute to the interactions between bacteria and bacterium-host. Since these nanostructures play significant role in pathogenesis, gene transduction, regulation of gene expression, immune response regulation, and cellular signaling, further studies are needed on the medical application of these nanostructures as a new generation of vaccines, adjuvants, drug delivery agents.
Keywords:
Extracellular vesicles , Adjuvants , Vaccine , Bacterium , Medical application , وزیکول های خارج سلولی , ادجوانت , واکسن , باکتری , کاربرد پزشکیی
Authors
Maryam Ebrahimi Vargoorani
Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran
Mohammad Hossein Modarressi
Department of Medical Genetics, Faculty of Medicine, University of Tehran, Tehran, Iran
Mojgan Sheikhpour
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
Seyed Davar Siadat
Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran
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