Chlorosulfonic acid supported Piperidine-۴-carboxylic acid (PPCA) functionalized Fe۳O۴ nanoparticles (Nano Fe۳O۴-PPCA): as a Green and Nano Catalyst for the Synthesis of ۲-Aryl-۵-methyl-۲,۳-dihydro-۱H-۳-pyrazolones and antibacterial evaluation

An efficient one-pot synthesis of ۲-aryl-۵-methyl-۲,۳-dihydro-۱H-۳-pyrazolones derivatives by a simple, atom-economical and four-component sequential reaction of phenyl hydrazine, methyl acetoacetate, aromatic aldehydes and β-naphthol in the presence of chlorosulfonic acid supported Piperidine-۴-carboxylic acid (PPCA) functionalized Fe۳O۴ nanoparticles (Nano Fe۳O۴-PPCA) as a more robust and efficient catalyst free in good to excellent yields is reported. ۲-aryl-۵-methyl-۲,۳-dihydro-۱H-۳-pyrazolones derivatives are one of the more effective antibiotics against bacteria.

Keywords:

۲-Aryl-۵-methyl-۲ , ۳-dihydro-۱H-۳-pyrazolones , chlorosulfonic acid supported Piperidine-۴-carboxylic acid (PPCA) functionalized Fe۳O۴ nanoparticles (Nano Fe۳O۴-PPCA) , Nano catalyst , antibiotics products