Prevalence and Antimicrobial susceptibility of Haemophilus influenza among healthy children in Mashhad

ntroduction: Nasopharyngeal colonization of Haemophilus influenza in young children may be important so in this study the nasopharyngeal carriage and antimicrobial susceptibility of Haemophilus influenza among children was surveyed in Mashhad. Materials and Methods: The study included ۱۱۶۱ healthy children less than ۶ years of age. Nasopharyngeal swabs from these patients were cultured, and Haemophilus influenza were isolated. Antibiotic susceptibility of the strains was determined using disk diffusion. Results: The carriage rate of Haemophilus influenza was ۱۰.۷۶% (۱۲۵/۱۱۶۱). High antibiotic resistance was observed against commonly administered antibiotics like Penicillin (۸۲.۴%), ampicillin (۷۰.۴%), Amoxicillin (۷۹.۲%) and trimethoprim sulfamethoxazole (۷۱.۲%). It was found that ۶۸.۸% and ۴۲.۴% of isolates were susceptible against erythromycin and cefexim, respectively.Conclusion: H. influenza isolates from healthy Children in Mashhad had high resistance rates against ampicillin, Sulphamethoxsusceptibility investigations are important for choice of therapy in every acute respiratory tract infection. And further monitoring of antibiotic resistance among nasopharyngeal H. influenza as a surrogate for invasive H. influenza seems an attractive option.

Keywords:

Haemophilus influenza , Bacteria , Antibiotic resistanceazole/ trimethoprim and some other antibiotics. So antibiotic