FokI and BsmI Polymorphisms of the VDR Gene and Breast Cancer Risk

Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women in West Azerbaijan Province, Iran. Methods: FokI and BsmI polymorphisms were studied through the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique on blood samples taken from ۹۵ cancer and ۷۱ healthy participants from Urmia City. The association between the mentioned polymorphisms and breast cancer risk was considered using calculated odds ratio (OR). Results: The findings showed the protective effect of the FokI polymorphism in breast cancer development (OR = ۰.۲۷۳۱), while no statistically significant correlation was observed between breast cancer and BsmI polymorphism (P > ۰.۰۵). Conclusions: This study identified the protective effect of the FokI polymorphism in breast cancer, and the absence of statistically significant association between BsmI polymorphism and breast cancer.

Keywords:

Breast Cancer , Calcitriol Receptors , Polymorphism , RFLP.