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Potential role of saffron and its components on miRNA levels in various disorders, a comprehensive review

Publish place: Iranian Journal of Basic Medical Sciences، Vol: 26، Issue: 10
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1738483

شناسه ملی سند علمی:

JR_IJBMS-26-10_002

تاریخ نمایه سازی: 4 شهریور 1402

Abstract:

The potential therapeutic benefits of saffron and its active constituents have been investigated for the treatment of numerous illnesses. In this review, the impacts of saffron and its essential components on the levels of microRNAs (miRNAs) in different diseases have been delineated. Relevant articles were obtained through databases such as PubMed, Web of Sciences, Scopus, and Google Scholar up to the end of November ۲۰۲۲. miRNA expression has been altered by saffron and its active substances (crocin, crocetin, and safranal) which has been of great advantage in treating diseases such as cardiovascular, type ۲ diabetes, cancers, gastrointestinal and liver disorders, central and peripheral nervous system disorders, asthma, osteoarthritis, ischemic-reperfusion induced injury conditions, and renal disorder. This study uncovered the potential restorative advantages of saffron and its derivatives, in miRNA imbalances in a variety of diseases.

Keywords:

Crocetin , Crocin , miRNAs , Saffron , Safranal

Authors

Mohammad Reza Aslani

Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

Farshad Armin

Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

Ali Abedi

Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

Elham Keramati

Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

Hassan Ghobadi

Lung Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran

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