Corrected Anion Gap and Hypernatremia as Predictors of Mortality in Pediatric Intensive Care Unit, Minia University Hospital: A Retrospective Study

BackgroundHypernatremia commonly occurs in ICUs, mostly developing soon after admission. It has been associated with prolonged ICU stay and has a mortality rate of ۴۰–۶۰%. The aim of our study is to estimate the values of serum anion gap (AG), corrected anion gap (CAG), and hypernatremia for an early prediction of mortality in pediatric intensive care units (PICUs).Materials and MethodsThis retrospective comparative study used data collected from the records of children admitted to the PICU at Minia University Hospital between June, ۲۰۱۷ and June, ۲۰۱۹.ResultsPatients were from ۱ month to ۱۸ years old. ROC curve analysis for the prediction of mortality showed the cutoff point of Na >۱۵۴ (۶۴.۰۴% sensitivity and ۷۹.۷۵% specificity) and of cAG > ۴۲.۱ (۵۷.۳۷% sensitivity and ۷۰.۲۵% specificity).ConclusionVentilation, respiratory failure, severe and moderate GCS, PH, CO۲, anion gap, high cAG, hypernatremia, K, CL, CRP, PLT, and creatinine were significant predictors of mortality among children admitted to the PICU.

Keywords:

Anion gap , Corrected anion gap , Hypernatremia , Pediatric intensive care unit