Molecular Aspects of Co-morbidities in COVID-۱۹ Infection
Publish place: The Archives of Bone and Joint Surgery، Vol: 8، Issue: 0
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
View: 89
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_TABO-8-0_004
تاریخ نمایه سازی: 5 شهریور 1402
Abstract:
Coronaviruses are a group of enveloped viruses with single-stranded non-segmented positive-sense RNA genomes. InDecember ۲۰۱۹, SARS-CoV-۲ appeared in China for the first time and quickly spread throughout the world. Althoughcertain medications suggested for other afflictions tend to be potentially effective for curing the infection, there is noapproved vaccination or drug available for this virus yet. Comprehension of the disease molecular pathogenesis couldprovide useful tools for COVID-۱۹ patients in surveillance, prognosis, treatment, vaccine development and therapeutictargeting. The present research aims to summarize the association in COVID-۱۹ patients between molecular dimensionsof comorbidities with clinical and preclinical information.Developing an ACE۲ inhibitor could be a possible therapeutic target. Plasmin is another possible candidate both indiagnosis and treatment areas. All predicted biomarkers must be validated either through randomized clinical trials orexperimental assays before clinical application in patients.Level of evidence: V
Keywords:
Cancer , Cardiovascular , Chronic Obstructive Pulmonary Disease , COVID-۱۹ , Diabetes Mellitus , Hypertension
Authors
Farzaneh Pouya
۱ Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ۲ Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Zeynab Imani Saber
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Amin Kerachian
۱ Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran ۲ Department of Medical Genetics, Faculty of Medicine
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :