Molecular Aspects of Co-morbidities in COVID-۱۹ Infection

Coronaviruses are a group of enveloped viruses with single-stranded non-segmented positive-sense RNA genomes. InDecember ۲۰۱۹, SARS-CoV-۲ appeared in China for the first time and quickly spread throughout the world. Althoughcertain medications suggested for other afflictions tend to be potentially effective for curing the infection, there is noapproved vaccination or drug available for this virus yet. Comprehension of the disease molecular pathogenesis couldprovide useful tools for COVID-۱۹ patients in surveillance, prognosis, treatment, vaccine development and therapeutictargeting. The present research aims to summarize the association in COVID-۱۹ patients between molecular dimensionsof comorbidities with clinical and preclinical information.Developing an ACE۲ inhibitor could be a possible therapeutic target. Plasmin is another possible candidate both indiagnosis and treatment areas. All predicted biomarkers must be validated either through randomized clinical trials orexperimental assays before clinical application in patients.Level of evidence: V

Keywords:

Cancer , Cardiovascular , Chronic Obstructive Pulmonary Disease , COVID-۱۹ , Diabetes Mellitus , Hypertension