Glycerol-Water Green Solvent for Bioactive Metabolites Extraction from Ranunculus arvensis and Extraction Optimization by Response Surface Methodology
Publish place: Asian Journal of Green Chmistry، Vol: 7، Issue: 4
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJGC-7-4_007
تاریخ نمایه سازی: 11 شهریور 1402
Abstract:
Ranunculus arvensis L. is a medicinal herb traditionally used for various purposes. The objective of the present research project was to find an effective and green method for obtaining bioactive natural products from it. Aqueous glycerol was employed as a green extracting medium, and the bioactive compounds were estimated as total flavonoid content (TFC) total phenolic content (TPC), antioxidant activity, and metal chelating activity (MCA). Response surface methodology (RSM) was applied to optimize the extraction process with temperature, time, and solvent (glycerol) concentration as input factors. The optimized conditions were ۳۰ °C, ۳۰ min, and ۷۰% glycerol concentration at which the responses were TPC ۷.۱۵ mg gallic acid equivalents/g DW (dry weight), TFC ۱۴.۸ mg rutin equivalents/g DW, antioxidant ۵۹.۵۵%, and MCA ۴۹.۱۴%. The model was strongly supported by the validation study. The explored extraction process for bioactive natural products from R. arvensis is predictably applicable. Hence, ۷۰% aqueous glycerol at almost room temperature and a minimum duration of ۳۰ min can allow optimum extraction of phenolics, flavonoids, antioxidants, and metal chelators from R. arvensis.
Keywords:
Ranunculus arvensis Polyphenols Glycerol , water green solvent Extraction optimization Response surface methodology
Authors
Sana Anayat
Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan
Dildar Ahmed
Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan
Mahnoor Anis
Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan
Nida Anis
Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan
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