Anticancer, antimicrobial, cardioprotective, and neuroprotective activities of luteolin: A systematic-narrative mini-review

Luteolin is a flavone subclass of flavonoids usually available as glycosylated forms in plant species. The low aqueous solubility or bioavailability of this herbal compound is the dominant limitation for its clinical formulation. The benzylation of the hydroxy groups at ۷-, ۳′- and ۴′- positions improves the oral bioavailability of this phytoactive compound. We systematically searched the biomedical database of PubMed to categorize related studies about luteolin with antimicrobial, anticancer, cardio protective, and neuroprotective activities from ۱۹۴۶ to May ۲۰۲۳. Literatures were analyzed based on data extracted from PubMed, an online, researchable database. The minimum and maximum number of publications was indicated respectively for antifungal and anticancer activities of luteolin in ۲۰۲۱-۲۰۲۲. In the case of cancers, breast and lung cancers have demonstrated a higher number of publications compared to prostate and uterine cancers. Moreover, luteolin has been evaluated significantly for Alzheimer’s disease and hypertension.

Keywords:

Phytoactive compound , Breast cancers , Alzheimer’ s Disease , Hypertension , PubMed database