Quantification of Langlois Reagent by ۱۹F-NMR Spectroscopy

Sodium trifluoromethanesulfinate (NaTFMS) is also known as “Laglois reagent” developed Quantitative ۱۹F-NMR (QNMR) and also employed to determine the amounts of “Laglois reagent” in a mixture containing (NaTFMS) and other inorganic impurities, the amounts of NaTFMS can be measured by high-performance liquid chromatography, but it requires a high-purity standard sample.  NMR signal was affecting the response to determined by measuring longitudinal relaxation time (T۱) to be ۱.۲ s is the main parameter ‘‘delay time (d۱) between two scans”. Internal reference for the quantitative analysis was used as a trifluoroethanol of sodium trifluoromethane sulphinate by water as solvent. Six experiments with different weights of sodium NaTFMS/TFE and the relative standard deviation (R.S.D.) were repeated and the results are less than ۲.۰% and also detection limit of ۱۹F-QNMR upto ۰.۸۵ mg. ۱۹F-QNMR was calculated and the R.S.D.s of results were less than ۲% of each mixture of amount NaTFMS.

Keywords:

Langlois reagent , NaTFMS , ۱۹F-QNMR , Trifluoroethanol (TFE) , Delay time (d۱)