A Facile and Green Approach for One-Pot Synthesis of New Pyrrole Derivatives by Three-Component Reaction Between Pyrrole, Arylglyoxals and Meldrum's Acid

An efficient one-pot three-component reaction of pyrrole with arylglyoxal derivatives and Meldrum’s acid (MA) in water at room temperature afforded ۲,۲-dimethyl-۵- (۲-oxo-۲-aryl-۱- (۱H-pyrrol-۲-yl) ethyl) -۱,۳-dioxane-۴,۶-dione derivatives under catalyst-free conditions in high yields. Products were isolated and purified by simple filtration and washing with diethyl ether and their structures were established from their IR and NMR spectroscopic data.

Keywords:

Pyrrole , Arylglyoxals , Meldrum's acid , Green synthesis , Three-component reaction