Green Multicomponent Synthesis of Benzodiazepines in the Presence of CuFe۲O۴ as an Efficient Magnetically Recyclable Nanocatalyst under Solvent-Free Ball-Milling Conditions at Room Temperature
Publish place: Organic Chemistry Research، Vol: 4، Issue: 1
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ORGC-4-1_008
تاریخ نمایه سازی: 3 مهر 1402
Abstract:
In this work, an efficient and green procedure for the synthesis of various substituted ۱,۵-benzodiazepine derivatives via a one-pot three-component catalytic reaction has been described. The reaction was conducted between o-phenylenediamine, dimedone and aldehyde derivatives in the presence of CuFe۲O۴ nanoparticles as a magnetic heterogeneous nanocatalyst under ball-milling conditions at room temperature. High yields of the products, short reaction times, simplicity of operation, mild reaction conditions, non-toxicity, easy work-up and purification of the products through crystallization method (chromatography-free) and recyclability of the catalyst are added advantages of this work.
Authors
Ali Maleki
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran
Razieh Firouzi-Haji
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran
Parisa Farahani
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran