An Efficient Synthesis of ۳,۴-Dihydropyrimidin-۲-(۱H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions

An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions abstract

An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives using antimony trichloride (SbCl3) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products are characterized by melting points and 1H NMR spectroscopy.

An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions Keywords:

Antimony trichloride (SbCl3) , 3 , 4-Dihydropyrimidinone , Multi-component synthesis , Biginelli reaction

An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions authors

Farzaneh Mohamadpour

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box ۹۸۱۳۵-۶۷۴ Zahedan, Iran

Malek Taher Maghsoodlu

Sistan &amp; Baluchestan University, Zahedan, IRAN

Reza Heydari

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box ۹۸۱۳۵-۶۷۴ Zahedan, Iran

Mojtaba Lashkari

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box ۹۸۱۳۵-۶۷۴ Zahedan, Iran

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https://civilica.com/doc/1766315

Document National Code:

JR_ORGC-2-2_004

Index date: 25 September 2023

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Mohamadpour, Farzaneh and Maghsoodlu, Malek Taher and Heydari, Reza and Lashkari, Mojtaba,1395,An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions,https://civilica.com/doc/1766315

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Type of center: دانشگاه دولتی

Paper count: 16,218

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