An Efficient Synthesis of ۳,۴-Dihydropyrimidin-۲-(۱H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions

An efficient and simple one-pot approach for the synthesis of ۳,۴-dihydropyrimidin-۲-(۱H)-one derivatives using antimony trichloride (SbCl۳) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products are characterized by melting points and ۱H NMR spectroscopy.

Keywords:

Antimony trichloride (SbCl۳) , ۳ , ۴-Dihydropyrimidinone , Multi-component synthesis , Biginelli reaction