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Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide

Publish place: Organic Chemistry Research، Vol: 1، Issue: 1
Publish Year: 1394
Type: Journal paper
Language: English
View: 125

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Link to this Paper:
https://civilica.com/doc/1766335

Document National Code:

JR_ORGC-1-1_004

Index date: 25 September 2023

Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide abstract

A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly catalyst.

Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide Keywords:

Strecker reaction , Protected α-amino acid , Heteropoly acid , Phosphotungstic acid , Trimethylsilyl cyanide , Environmentally friendly catalyst , Diastereoselectivity

Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide authors

Saeed Balalaie

Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran Fax: +۹۸-۲۱-۲۲۸۵ ۳۶۵۰ , Balalaie@kntu.ac.ir&Balalaie@yahoo.com

Fatemeh Tahoori

Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran

Negin Khatibi

Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: ۱۵۸۷۵-۴۴۱۶, Tehran, Iran