Synthesis of ۶-Amino-۴-aryl-۳-methyl-۱,۴-dihydropyrano[۲,۳-c]pyrazole-۵-carbonitriles in the Presence of Reusable Catalyst "Celloluse"

Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of ۶-amino-۴-aryl-۳-methyl-۱,۴-dihydropyrano[۲,۳-c]pyrazole-۵-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and good yields of the products are advantages of this method.

Keywords:

Cellulose , Reusable catalyst , ۱ , ۴-Dihydropyrano[۲ , ۳-c]pyrazole , Solvent-free condition , Aryl aldehyde , Hydrazine monohydrate