Evaluation of Antimicrobial Activity of Some Hybrids of Pyrimidine-Azole Derivatives along with Molecular docking study
Publish place: Trends in Pharmaceutical Sciences، Vol: 9، Issue: 3
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 78
This Paper With 8 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_TIPS-9-3_003
تاریخ نمایه سازی: 9 آبان 1402
Abstract:
Despite extensive research on antimicrobial drugs, efforts to find suitable alternatives to older drugs have not been very successful yet, due to microbial resistance. Heterocycles including azole and pyrimidine derivatives were used to design antimicrobial activity in this research, ۱۲ novel pyrimidine-azole derivatives (۳a-۳l) that were previously synthesized were screened for their antibacterial and antifungal activities by using CLSI standard method. In this study, we used four species of bacteria, seven species of fungi, and five species of yeast. Molecular docking studies were also performed to investigate their binding mode and orientation toward lanosterol ۱۴-α- demethylase (CYP۵۱), as a plausible mechanism of azole antifungal compounds. The biological results showed that none of the compounds had antibacterial and antifungal effects compared to the control drugs. The molecular docking study showed that the compounds had a low binding affinity in the active site of the lanosterol ۱۴-α- demethylase target, which confirmed the weak antifungal and antibacterial activities of these compounds.
Keywords:
Authors
Leila Emami
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Zare
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Kamiar Zomorodian
Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mahshid Saber Nazar Agha
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Razieh Sabet
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :