Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)

Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of ۱۶۰ mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and Methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=۳۳) and placebo (n=۳۳) groups and at the end of the study, the data of ۵۶ participants who completed the ۲-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received ۱۶۰ mg/day of nano-micelle curcumin in two divided doses for ۶۰ days. The ۲ groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p<۰.۰۱) as well as a significant difference between the groups before and after the intervention in curcumin group (p<۰.۰۵). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p<۰.۰۱). Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD.

Keywords:

Non-alcoholic fatty liver disease , Curcumin , Nano-micelle , Hepatic enzymes