Assessment of Insulin Resistance with Two Methods: HOMA-IR and TyG Index in Iranian Obese Women

Objective: The aim of the present study is assessment of insulin resistance (IR) in obese women by TyG-Index and compared with the HOMA-IR index. Materials and Methods: This cross-sectional study was performed on ۶۱ obese women aged ۱۸-۴۵ years. Weights, height, waist circumference (WC) were measured and body mass index (BMI) was calculated and recorded. A sample of fasting serum was collected to determine the glucose, triglyceride, insulin, total cholesterol, HDL-C and LDL-C concentration. HOMA-IR and TyG-Index were calculated as markers of insulin resistance. Results: The mean age of the precipitants was ۳۲.۵ ±۰.۷۹ years old and the mean weight was ۸۶.۰±۱.۷ Kg. The number of people with IR who determined by HOMA and TyG index were ۲۱(۳۴%) and ۳۶(۶۱%), respectively. There was a significant relationship between HOMA-IR and TyG Index, r= ۰.۰۴۴ (P<۰.۰۰۱). Conclusion: TyG index represents a useful and accessible tool for assessment of IR instead HOMA_IR in Iranian population, but more researches with greater sample size and via gold standard lab test need to evaluate the specificity and sensitivity of this new method.

Keywords:

TyG-Index , HOMA-IR , Obesity