Serum Glucagon-Like Peptide-۱ Changes in Women with Type ۲ Diabetes Following a Four Weeks Aerobic Exercise

Objective: The objective of this study was to investigate the effect of four weeks aerobic training on serum glucagon-like peptide-۱ (GLP-۱) in women with type ۲ diabetes mellitus (T۲DM). Materials and Methods: Twenty T۲DM patients (۳۳-۵۳ years) were randomly assigned into control (n=۱۰) and experimental (n=۱۰) groups. The main intervention included running on treadmill, reaching ۵۵ to ۸۰% of the maximum heart rate (five times by week) done for ۳۰ minutes in the first session and increasing gradually to ۶۰ minutes by the end of the fourth week. Blood samples were collected before and after ۴ weeks, and the concentrations of serum GLP-۱ and insulin were determined using separate ELISA and the glucose concentrations was determined by biochemical methods. Results Statistical analysis showed that after four weeks of aerobic training, the serum levels of GLP-۱, glucose and insulin related to the experimental group had no significant difference in comparison with control group (P>۰.۰۵). Conclusion: The results indicate that doing the aerobic training five times a week during four weeks with ۵۵ to ۸۰ percent of maximum heart rate has no effect on GLP-۱ serum levels, glucose and insulin in T۲DM women.

Keywords:

Aerobic exercise , GLP-۱ , Type ۲ diabetes