The Effect of Selenium on Micro-Albuminuria in Diabetic Patients: A Randomized Clinical Trial
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 12، Issue: 4
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-12-4_001
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
Objective: Oxidative stress plays an important role in the onset and progression of diabetic nephropathy. So antioxidant agents may be one of the key treatment strategies for prevention of diabetic nephropathy progression .The aim of this study was to determine the effect of selenium (Se) on micro-albuminuria in type ۲ diabetic (T۲DM) patients.
Materials and Methods: This study was a clinical study on ۶۰ T۲DM patients with micro-albuminuria who were referred to Yazd diabetic research center from March ۲۰۱۶ till April ۲۰۱۷. Patients were randomized in to two groups: Se (۲۰۰ microgram Se daily) and control. The control group did not receive placebo. The intervention duration was ۱۲ weeks. Micro-albuminuria, fasting blood sugar (FBS), cholesterol, triglycerides, HDL-C, LDL-C, urea, creatinine, HbA۱c, plasma Se concentration were measured at the baseline and after ۱۲ weeks.
Results: Micro-albuminuria decreased after ۱۲ weeks in both studied groups but it was not statistically significant. Cholesterol and LDL levels improved statistically in both studied groups at the end of study (P-value: ۰.۰۳۴, ۰.۰۲۳ respectively). Plasma Se level increased in intervention group (P-value< ۰.۰۰۱). There were clinically improvement in other studied variables after ۱۲ weeks in two studied groups but not statistically significant
Conclusion: Our study demonstrated that Se supplementation for ۱۲ weeks among patients with micro-albuminuria had no beneficial effects on micro albuminuria.
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Authors
Akram Ghadiri-Anari
Associate Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Saeedeh Jam-Ashkezari
Researcher, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Bahareh Fallah-Tafti
Nursing, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Masoud Rahmanian
Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Maryam dehghan
MD, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Nasim Namiranian
Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran