Vitamin D Deficiency and Psoriasis: A Cross-Sectional study of Iranian Population in Yazd Province
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 12، Issue: 3
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-12-3_007
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
Objective: Psoriasis is an inflammatory disease of the skin and the joints. Psoriatic patients sometimes suffer from vitamin D deficiency and hypocalcemia. The aim of our study was to evaluate the level of calcium and vitamin D in patients with psoriasis.
Materials and Methods: In this analytical cross sectional study, ۱۱۰ cases of psoriasis that were referred to Shohadaye Mehrab clinic during ۲۰۱۵ and ۱۱۰ non-psoriatic patients enrolled. Serum levels of calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphatase (ALK) and ۲۵- hydroxy vitamin D۳ [(۲۵OH) D۳] were measured in both groups. Data were analyzed using SPSS software version ۱۹. Chi square test and T-test were used for statistical analysis.
Results: Among۱۱۰ patients with psoriasis ۷۴ (۶۷.۳%) were men and ۳۶ (۳۲.۷۵%) were women. There was no significant difference in the serum level of calcium (P-value: ۰.۵۶۳), phosphorus (P-value: ۰.۳۸۱), PTH (P-value: ۰.۳۶۴) and ALK (P-value: ۰.۶۳۹) between two groups. Vitamin D deficiency was found in ۶۴.۵% of psoriatic patients and ۶۰% of the controls (P-value= ۰.۴۵); However ۳۰.۹% of psoriatic and ۱۷.۳% of the controls suffered from severe hypovitaminosis D. This difference was statistically significant (P-value= ۰.۰۱۴).
Conclusion: We found a significant relationship between severe hypovitaminosis D and psoriasis. This finding revealed the need for evaluation of psoriatic patients for the presence of vitamin D deficiency.
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Authors
Mohammad Ebrahimzadeh Ardakani
Department of Dermatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad Afkhami-Ardekani
Yazd Diabetes Research center, Shahid Sadoughi University of Medical Sciences Yazd, Iran
Mohammad Reza Taghizadeh Yazdi
Departments of Industrial Management, University of Tehran, Tehran, Iran
Nasim Namiranian
Yazd Diabetes Research center, Shahid Sadoughi University of Medical Sciences Yazd, Iran
Farideh Radmehr
Department of Dermatology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran