The Effect of ۱۲ Weeks Aerobic Training on PDX-۱ and GLUT۲ Gene Expression in the Pancreatic Tissue of Type ۲ Diabetic Rats
Publish place: Iranian Journal of Diabetes and Obesity، Vol: 12، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJDO-12-2_007
تاریخ نمایه سازی: 16 آبان 1402
Abstract:
Objective: The aim of this study was to investigate the effect of ۱۲ weeks aerobic training on PDX-۱ and GLUT۲ gene expression in the pancreatic tissue of type ۲ diabetic rats.
Materials and Methods: ۲۱ wistar male rats were placed in ۳ groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted ۱۲ weeks, five sessions per week by gradual increase of speed (۱۸ to ۲۶ meters on minutes) and time (۱۰ to ۵۵ minutes) in the form of running on the treadmill. After ۱۲ week aerobic training, PDX-۱ and GLUT-۲ genes were measured. Data was analyzed using ANOVA with ۵ % significance level.
Results: Aerobic training caused a significant increase in the expression of GLUT۲ (P-value: ۰.۰۴۳) and PDX-۱ genes (P-value: ۰.۰۰۷) in the pancreatic tissue of rats with type ۲ diabetes (p value: ۰.۰۵). Also aerobic training had a significant effect on serum glucose (P-value: ۰.۰۰۱) and insulin levels (P-value: ۰.۰۰۱).
Conclusion: It is concluded that aerobic training has significant effects on diabetic control by increasing the expression of PDX۱ and GLUT-۲ which lowers serum glucose.
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Authors
Shokoufeh Sokhanvardastjerdi
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran
Abdolali Banaeifar
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran
Sajad Arshadi
Department of Exercise Physiology, Islamic Azad University, South Tehran Branch, Tehran, Iran
Aredeshir Zafari
Department of Exercise Physiology, Islamic Azad University, Zanjan Branch, Zanjan, Iran
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