Effect of Black Grape Seed(Vitis Vinifera) Extract Consumption with Moderate-Intensity Aerobic Training on the Expression of MicroRNAs in Type ۱ Diabetic Cardiac Tissue Rats

Objective: This study aimed to evaluate the effect of consuming grape seed extract with moderate-intensity aerobic training on the expression of miR-۱۲۶ and miR-۲۹ in the cardiac tissue in type ۱ diabetic male rats. Materials and Methods: ۴۰ rats with an initial weight range of ۱۶۰-۲۲۰ g were divided into five groups: Training + Extract, Training, Extract, Diabetic / Control, and Healthy / Control. Aerobic training program was moderate intensity and rats performed aerobic training for ۶۰ minutes a day with the intensity ۷۰ to ۷۵% of maximum oxygen consumption (۲۸ meters per minute). Grape seed extract was also administered by gavage at a dose of ۴۰ mg/kg per day. Results: Expression of both miRNAs in the three groups of training + extract, healthy training and control was significantly higher than the two groups of extract and diabetic control (P-value= ۰.۰۰۱). The difference between the three groups of training + extract, healthy training and control and also the difference between the two groups of extract and diabetic control were not significant (P-value> ۰.۰۵). Conclusion: Aerobic training may be able to prevent cardiac disease caused by type ۱ diabetes.

Keywords:

Diabetes , Aerobic training , Grape Seed , miR-۱۲۶ , miR-۲۹a