Renal function in patients with rheumatoid arthritis in Rafsanjan city in ۲۰۲۱

Renal involvement is one of the extra-articular manifestations of rheumatoid arthritis (RA). The current study aims to investigate renal function and its associated factors in RA patients. This cross-sectional study included ۴۴۳ RA patients who were referred to Rafsanjan's only rheumatology clinic in ۲۰۲۱. Disease Activity Score ۲۸ (DAS۲۸) index was used to determine disease activity. Blood levels of creatinine, C-Reactive Protein test (CRP), Erythrocyte Sedimentation Rate (ESR), and urine analysis were also determined. Renal failure was classified based on Estimated Glomerular Filtration Rate (eGFR). SPSS.۲۰ one-way ANOVA, Kruskal-Wallis test, the Mann-Whitney U test, and Chi-square were used to analyze the data. Patiens' mean age was ۵۳.۹۹ ± ۱۲.۳۴, and ۸۵.۸% (۳۸۰ people) of the participants were female. Ther were ۱۴۷ (۳۳.۲%) patients without renal failure, ۲۶۰ (۵۸.۷%) with mild renal failure, and ۳۶ (۸.۱%) with moderate/severe failure. Men had a ۳.۰۵۹ higher risk of renal failure than women (P = ۰.۰۰۱). The probability of developing renal failure in patients increased by ۱.۰۴۷ times with each year of age (P < ۰.۰۰۱). As a chronic disease, RA can directly or through the use of disease medications and other risk factors, adversely affect other organs of the body, including the kidney. The current study's findings revealed a high prevalence of mild renal failure in these patients.

Keywords:

Rheumatoid arthritis , renal failure , Creatinine , C-reactive protein , erythrocyte sedimentation rate