The Effectiveness of Acupuncture on Cortisol Levels in a Prostate-Carcinoma Patient under Androgen Deprivation Therapy with Dysthymic Syndrome: A Single-case Experimental Design
Publish place: Middle East Journal of Cancer، Vol: 11، Issue: 2
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
View: 143
This Paper With 6 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_MISJ-11-2_015
تاریخ نمایه سازی: 25 آبان 1402
Abstract:
The prevalence of suicide is high in patients with prostate cancer. The hypothalamic– pituitary–adrenal (HPA) axis disorder plays a role in the pathophysiology of depression and suicidal ideation. Acupuncture regulates cortisol secretion through controlling the activity of HPA axis. The purpose of this study was to evaluate the effectiveness of acupuncture on decreasing depression, suicidal ideation, and cortisol secretion in a patient with prostate cancer. In a single-case experimental study, lasting from December ۲۰۱۵ to June ۲۰۱۶, a patient suffering from prostate carcinoma with dysthymic disorder and suicidal ideation was selected through purposive sampling method. Following ۳۰ days of evaluation at baseline, the subject was treated for four weeks with auricular acupuncture along with the usual treatment. The results were analyzed by generalized estimation equation (GEE) and Repeated Measures Correlation (rmcorr) through statistical package for the social sciences (SPSS) software version ۲۲. The primary outcomes showed that acupuncture had a significant effect on reducing depression index, suicidal ideation, and cortisol levels during the treatment process (all P values< ۰.۰۵). Secondary outcomes further showed that a significant positive correlation existed between depression, suicidal ideation, and salivary cortisol levels (all P values < ۰.۰۵). The findings of this study showed that auricular acupuncture can replace medication and psychotherapy to reduce depression and suicidal ideation and regulate HPA-axis function through modulating the cortisol secretion. However, this conclusion requires more high-quality randomized clinical trials.
Keywords:
Authors
Bijan Pirnia
Department of Psychology, Faculty of Humanities, University of Science and Culture, Tehran, Iran
Kambiz Pirnia
Bijan Center for Substance Abuse Treatment, Tehran, Iran
Shaniya Haghighat
Department of Psychology, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
Parastoo Malekanmehr
Department of Psychology, Faculty of Psychology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Alireza Zahiroddin
Department of Psychiatry, Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran