Clinicopathological Characteristics of Patients with BRCA Mutation Breast Cancer in North Sumatera: Case Report

The most common cancer in women is breast cancer (BC) with an incidence of ۲۴.۲%. BC in younger patients will in general be more forceful, prompting more awful results and a requirement for more forceful treatment which may bring about a higher probability of long-haul treatment-related harmfulness and novel psychosocial issues. Furthermore, family inclination to BC as BRCA۱ and BRCA۲ mutations is more prevalent in this age group. There were a total of five ladies who had tumor pathology testing with negative results. All intrusive BC examples were regularly assessed for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-۲ (HER۲)/neu status utilizing immunohistochemistry. Cases with HER۲/neu staining of ۱+, ۲+ or ۳+ on immunohistochemistry examination were additionally assessed by fluorescent in situ hybridization for the enhancement of the HER۲/neu quality. In this examination, we distinguished clinicopathological attributes of patients with BC. We partitioned into two gatherings, BRCA positive change and BRCA negative transformation. Roughly ۵%-۱۰% instances of BC have a positive family ancestry and about ۲۰%-۴۰% BC development were in acquired variations. Our study revealed that ۲۰% of cases included individuals who had a family history of BRCA mutation. Male relatives with BC, earlier age at onset, a greater prevalence of reciprocal breast disease, and a connection to various malignancies in the ovary, colon, prostate, pancreas, and endometrial are only a few of the clear clinical characteristics of BRCA۱/۲-related BC.

Keywords:

Breast neoplasms , Genes , BRCA۱ , BRCA۲ , Immunohistochemistry